Figure 1.
A schematic model of SAg of S. aureus interaction with TCR and MHC class II molecules of an infected H. sapiens.
Here, one can find the difference between antigen and SAg binding site on TCR.
Figure 2.
agr and sar loci from S. aureus, adapted from [140].
Figure 3.
Gene regulatory network involving sarA family, agr and rot (transcriptional regulators) in SAg expression regulatory pathway of the S. aureus [27], [31].
Sharp arrow head indicates activation and blocked arrow head shows inhibition.
Figure 4.
TCR signaling pathway of H. sapiens.
SEB refers to Staphylococcal Enterotoxin B. Sharp arrow head indicates activation and blocked arrow shows inhibition.
Figure 5.
Diagram showing the studied biochemical pathways upon perturbed/unperturbed conditions, along with different conflicting objective functions.
Figure 6.
Displaying the concept behind the construction of integrated pathway system that includes SAg expression regulatory pathway of S. aureus and TCR signaling pathway of an infected host (H. sapiens).
Table 1.
Names of signaling molecules present in TCR signaling pathway of H. sapiens and the respective c-values for the regulators to form these signaling molecules in unperturbed/perturbed conditions in different cases as mentioned in Fig. 5.
Figure 7.
Graph shows optimization of two conflicting objective functions in an integrated pathway system of SAg expression regulatory pathway of S. aureus and TCR signaling pathway of an infected host (H. sapiens).
Here, is maximized, while
is minimized.
Figure 8.
Comparing -values [0–1] of the molecules present in TCR signaling pathway of H. sapiens in three cases: (1) in an unperturbed TCR signaling pathway, (2) in a perturbed one and (3) after applying conflicting objective function optimization (case 4) on the perturbed TCR signaling pathway.
Table 2.
Effects on some of the TCR signaling molecules upon perturbing the concentrations of ZAP70, LCK and FYN for unperturbed and perturbed TCR signaling pathways of H. sapiens.
Table 3.
Comparison of some of the computed c-values for given signaling molecules with the existing experimental evidences, for biological validation purpose.