Figure 1.
Secretion of ceruloplasmin from fat cells.
A. Secretion during differentiation of progenitor cells to fat cells. Data are analysed by ANOVA, repeated measures. B and C. Influence of obesity on plasma levels and secretion from adipose tissue as analyzed with unpaired t-test. D. Relationship between secreted ceruloplasmin and its plasma levels as analyzed with linear regression.
Figure 2.
View of the ceruloplasmin (CP) locus in the human genome.
A. CP is located on on the negative (purple) strand of chromosome 3 at position 3q23-q25, flanked by HPS3 on the positive (green) strand and CPHL1 on the negative strand. B. RefSeq mRNA models of the locus. C. Promoter activity signal distribution as measured by CAGE in the locus. The majority of expression comes from the 5′ end of CP. D. Expression (tags per million, TPM) across the locus for the cell lines present in FANTOM5. Cell lines with expression above 10 TPM are shown here; in total 269 cell lines were profiled. Obesity associated cell lines are indicated by black (O.R. > = 1.30) and gray (O.R. > = 1.20) arrows.