Figure 1.
Flow chart illustrating the entire study population.
Figure 2.
Plasma CD4+/CD8+ count and overtime change at baseline, week 12, and week 48 in the two study arms in the intention to treat analysis.
A CD4+ count at baseline at week 12 and week 48 in arm A and B on the ITT analysis. CD4+ ITT analysis evidenced: in arm A a median count of 192 cell/µL at baseline, 212 cells/µL at week 12 and 223 cells/ µL at week 48; in arm B a median count of 169 cell/µL at baseline, 175 cells/µL at week 12 and 169 cells/µL at week 48. Box-plots (25% and 75% values) are presented.
B CD4+ count change from baseline at week 12 and week 48 in the two study arms in the intention to treat analysis. The vertical lines represent the standard deviation.
C CD8+ count at baseline at week 12 and week 48 in arm A and B on the ITT analysis. CD8+ ITT analysis evidenced: in arm A a median count of 580 cells/µL at baseline, 634 cells/µL at week 12 and 585 cells/µL at week 48; in arm B a median count of 725 cells/µL at baseline, 681 cells/µL at week 12 and 687 cells/µL at week 48. Box-plots (25% and 75% values) are presented.
D CD8+ count change from baseline at week 12 and week 48 in the two study arms in the intention to treat analysis. The vertical lines represent the standard deviation.
Figure 3.
Naive and memory T-cell phenotypes in Immunological Non Responders with and without HAART intensification with MVC.
A. Percentage of naive CD45RA+CD62L+CD4+ T-cells. B. Percentage of naïve CD45RA+CD62L+CD8+ T-cells. C. Percentage of memory CD45RA-CD4+ T-cells. D. Percentage of memory CD45RA-CD8+ T-cells.
The vertical lines represent median and interquartile ranges (25th and 75th percentiles).
Figure 4.
T-cells activation and proliferation in Immunological Non Responders with and without HAART intensification with MVC.
A-B. T-cell activation defined as the co-expression of HLA-DR and CD38 on CD4+ and CD8+.
C-D. T-cell proliferation defined as the expression of Ki67 on CD4+ and CD8+.
The vertical lines represent median and interquartile ranges (25th and 75th percentiles).
Figure 5.
IL-7/IL-7R system in Immunological Non Responders with and without HAART intensification with MVC.
A. Percentage of CD127+CD4+ T-cells. B. Percentage of CD127+CD8+ T-cells. C. Plasma levels of IL-7.
The vertical lines represent median and interquartile ranges (25th and 75th percentiles).