Figure 1.
Chemical structures of the angiotensin II type 1 receptor blockers EXP3174, which is an active metabolite of losartan, candesartan, valsartan, telmisartan, olmesartan, irbesartan and azilsartan.
Figure 2.
A. Position of the second extracellular loop (ECL2) in the model of AT1 receptor using bovine rhodopsin (orange) or CXCR4 (yellow) receptor as a template.
B. Molecular modeling of the interaction between olmesartan and the AT1 receptor. The AT1 receptor is shown as a ribbon and Tyr113, Lys199, His256, Gln257 and olmesartan are shown as stick models. Color notation in the helix is as follows: transmembrane (TM)1, orange; TM3, yellow; TM5, dark green; TM6, blue; and TM7, purple.
Figure 3.
Molecular modeling of the interactions between the 7 ARBs and the AT1 receptor.
Color notation in the helix is as follows: transmembrane (TM)1, orange; TM2, dark yellow; TM3, yellow; TM4, green; TM5, dark green; TM6, blue; and TM7, purple.
Figure 4.
Molecular modeling of a close-up view of the interactions between the 7 ARBs and the AT1 receptor.
Color notation in the helix is as follows: transmembrane (TM)1, orange; TM3, yellow; TM5, dark green; TM6, blue; and TM7, purple.
Figure 5.
Possible molecular modeling of the interactions between a lipophilic pocket (gray zone) in the AT1 receptor and telmisartan or irbesartan.
Color notation in the helix is as follows: transmembrane (TM)3, yellow; TM5, dark green; and TM6, blue.