Figure 1.
Manhattan plot and Q-Q plot of genome-wide meta-analysis.
(A) The Manhattan plot of the meta-analysis of Chinese, Malays and Indians. The minus log10 of P-values (Y-axis) of inverse-variance meta-analysis across the 22 autosomal chromosomes after genomic control were plotted against the genomic coordinates. The horizontal line represents the genome-wide significant level of 5x10-8. (B) Q-Q plot of the observed P-values (Y-axis) against the expected P-values (X-axis). The diagonal line and its 95% confidence envelop were also plotted.
Figure 2.
Bivariate plots of the effect sizes in Asian cohorts and European ancestry cohorts.
The effect sizes reported in the European ancestry were plotted against the ones discovered in our studies. The Y-axis corresponds to the European effect size, while the X-axis corresponds to the effect in Chinese (A), Indians (B), Malays (C) and Meta-analysis (D). The SNPs which are replicated in our studies at the P-value of 0.05 level were designated by red dots, while the SNPs failed to be replicated were designated by black dots. The SNPs with inconsistent effect directions between European and each population were labeled by the reported gene names.