Figure 1.
Middle liver fissure (red line), and liver interlobar fissure (black line) are used as a landmark to differentiate right liver lobe from left liver lobe, and left lateral liver lobe from left medial liver lobe on the level of the fossa for gallbladder, respectively (A). Middle liver vein (purple line), and left liver vein (blue line) are used as a landmark to differentiate right liver lobe from left liver lobe, and left lateral liver lobe from left medial liver lobe on the level of the second liver portal, respectively (B). The line (green line) linking the inferior vena cava to the right branch of the portal vein is used as a landmark to differentiate right liver lobe from the caudate lobe on the level of the first liver portal (C). Outlines of four hepatic lobes, and of spleen are delineated on the axial enhanced magnetic resonance imaging (D) (RL, right liver lobe; LML, left medial liver lobe; LLL, left lateral liver lobe; CL, caudate lobe; and S, spleen).
Figure 2.
Photomicrographs (original magnification, ×400; Masson’s trichrome stains) of histologic sections from liver biopsy specimens.
The figure shows the progression of fibrosis in minipigs: stage 1, portal fibrous expansion (A); stage 2, thin fibrous septa emanating from portal triads (B); stage 3, fibrous septa bridging portal triads and central veins (C); and stage 4, cirrhosis (D).
Figure 3.
Box plots of liver lobe volume parameters for each fibrosis stage.
The figure shows distributions of left lateral liver lobe volume (LLV, A), left medial liver lobe volume (LMV, B), right liver lobe volume (RV, C), and caudate lobe volume (CV, D) as well as the ratios of LLV to SV (LLV/SV, E), LMV to SV (LMV/SV, F), RV to SV (RV/SV, G), and CV to SV (CV/SV, H) stratified by fibrosis stages.
Figure 4.
Receiver operating characteristic curves of liver lobe volume parameters for classifying liver fibrosis stage ≥2 and ≥3.
The figure shows left lateral liver lobe volume (LLV), caudate lobe volume (CV) as well as the ratios of LLV to spleen volume (LLV/SV), left medial liver lobe volume to spleen volume (LMV/SV), right liver lobe volume to spleen volume (RV/SV), and caudate lobe volume to spleen volume (CV/SV) for classifying liver fibrosis stage ≥2 and ≥3.