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Figure 1.

Population for analysis.

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Table 1.

Baseline characteristics of the participants in different quartiles of uric acid levels.

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Figure 2.

Association of serum uric acid with kidney function in normotensive and hypertensive subjects (A) Annual decline in eGFR in relation to serum uric acid quartiles in hypertensive and normotensive participants.

Analyses are adjusted for age, sex and baseline eGFR. Quartiles are compared with participants in the first quartile of serum uric acid (<4.5 mg/dL) (B) Risk of incident CKD in relation to quartiles of serum uric acid level in hypertensive and normotensive participants. Analyses are adjusted for sex, age and baseline eGFR. All odds ratios are compared with participants in the first quartile of serum uric acid (<4.5 mg/dL).

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Table 2.

The association between serum uric acid (mg/dL) and decline in estimated glomerular filtration rate (ml/min per 1.73 m2).

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Table 3.

The association between serum uric acid (mg/dL) and incidence of chronic kidney disease.

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Figure 3.

Flow diagram of studies through the different phases of the meta-analysis.

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Figure 4.

Forest plot of multivariate adjusted relative risk for CKD incidence associated with continuous values of serum uric acid (mg/dL).

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