Table 1.
Demographic and neonatal characteristics.
Table 2.
Constrained principal component analysis results to explain variance in cortical thickness in relation to neonatal clinical factors.
Table 3.
Brain regions with loadings for the 3 components.
Table 4.
Constrained principal component analysis loadings for the 7 neonatal clinical factors to explain variance in cortical thickness.
Figure 1.
Cortical thickness at age 7 years in relation to neonatal pain-related stress adjusted for clinical confounders.
Cortical thickness in two of the brain regions where most significant (p≤0.0001) thinning in relation to neonatal pain-related stress was found. A) Scatter plot of right hemisphere postcentral cortical thickness in relation to neonatal pain-related stress (number of skin-breaking procedures log transformed) adjusted for gestational age, severity of illness on day 1, number of culture proven infection, number of days on mechanical ventilation, number of surgeries, and cumulative daily morphine dose in milligrams adjusted for daily body weight. B) Scatter plot of left hemisphere pars orbitalis cortical thickness in relation to neonatal pain-related stress (same as in A).
Table 5.
GENLIN results for the 21/66 cortical regions significantly associated with neonatal pain-related stress (adjusted for clinical confounders).
Table 6.
GENLIN results for the 5/66 cortical regions significantly associated with neonatal cumulative morphine exposure (adjusted for clinical confounders).