Figure 1.
Gomes histological classification of UC.
1A: Gomes 0 (normal); 1B: Gomes 1 (mild oedema and inflammation in lamina propria with cryptitis); 1C: Gomes 2 (crypt abscess formation and inflammation); 1D: Gomes 3 (destructive crypt abscesses +/ā granulomata); 1EāF: Gomes 4 (active ulceration and formation of granulation tissue with neoangiogenesis).
Table 1.
Baseline characteristics of patients with active UC.
Figure 2.
Median and interquartile range of LOX-related lipid mediators (pg/mg tissue) in grouped non-inflamed and adjacent inflamed mucosa with difference plots of paired samples.
2A: 11-HETE; 2B: 12-HETE; 2C: 15-HETE; 2D: 5-HETE.
Table 2.
Lipid mediator concentrations (pg/mg tissue) in colonic mucosa (inflamed and non-inflamed) in UC patients.
Figure 3.
Median and interquartile range of COX-related lipid mediators (pg/mg tissue) in grouped non-inflamed and adjacent inflamed mucosa with difference plots of paired samples.
3A: PGE2; 3B: PGD2; 3C: TXB2.
Figure 4.
Data separation of inflamed (triangle) and non-inflamed (circle) mucosa based on lipid mediator concentration.
4A: PCA score plot (unsupervised analysis); 4B: O2PLS-DA plot (supervised analysis).
Figure 5.
Variable importance plot in O2PLS-DA analysis demonstrates relative contribution of lipid mediators to separation between inflamed and non-inflamed mucosa.
(Fig. 4).
Figure 6.
O2PLS model showing computed prediction of disease severity based on lipid mediator profile.
6A: Plot showing O2PLS regression score plots; 6B: plot showing actual vs. predicted GOMES score based on lipid mediator profile.
Figure 7.
Variable importance plot in O2PLS analysis demonstrates relative contribution of lipid mediators to separation between histological grades of severity.
(Fig. 6).
Table 3.
Lipid mediator concentrations (pg/mg tissue) in colonic mucosa (inflamed and non-inflamed) in treatment naive UC.