Figure 1.
Endoscopic photographs from the same area of the stomach in patients 1 (a, b) and 2 (c, d) at baseline (a, c) and after 12 weeks of netazepide (b, d).
Figure 2.
Endoscopic tumour characteristics: (a) number of tumours; (b) size of largest tumour, and (c,d) % change from baseline after 6 and 12 weeks’ netazepide treatment, and at follow-up at 24 weeks, 12 weeks after end of treatment.
Figure 3.
Representative photomicrographs of gastric corpus (a-c) and a neuroendocrine tumour (d-f) from the same patient stained for H and E (a,d), chromogranin A (b.e) and synaptophysin (c,f).
Scale bar = 200µm.
Figure 4.
Fasting (a) plasma chromogranin A (U/L) and (b) serum gastrin (pmol/L) concentrations at baseline, after 3, 6, 9 and 12 weeks’ netazepide treatment, and at follow-up at 24 weeks, 12 weeks after end of treatment.
Figure 5.
Gastric corpus mucosal mRNA abundance of CgA (a), HDC (b), MMP-7 (c), PAI-1 (d) and PAI-2 (e) normalised to mRNA abundance of the housekeeper gene GAPDH.
Mean ± standard deviation of each biomarker after 6 and 12 weeks of netazepide treatment, and at follow-up at 24 weeks, 12 weeks after end of treatment (f). *p<0.05.