Figure 1.
Derivation of Study Cohort from N = 1720 symptomatic FDNY firefighters who presented for subspecialty pulmonary testing. Serum available and inclusion criteria met for N = 70/100 cases and N = 123/153 controls.
Table 1.
Demographics of Cohort.
Figure 2.
FEV1% Predicted based on NHANES of Serial PFTs of Cases and Controls.
Median and IQR are represented by box plots, with median drawn in the middle of the box. The extremes of the error bars (whiskers) represent 10–90% percentile.
Table 2.
Longitudinal Lung Function Assessment of Cohort.
Table 3.
Serum Biomarkers.
Figure 3.
Hierarchical Clustering of Serum MMPs.
Clustering of MMPs in the cohort, N = 193 showed that MMP3 and MMP-12 clustered together.
Table 4.
Models of Susceptibility to Lung Injury.*
Figure 4.
Probability of Developing WTC-LI.
Contour Plots express probability isopleths for the development of WTC-LI with all other covariates held constant. When either MMP-3 (A) or MMP-12 (B) increases, the probability of lung injury decreases. As time to blood draw increases, the probability of lung Injury increases.