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Table 1.

Ontology complexity metrics.

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Figure 1.

Evolution of the number of classes of the three branches of the Gene Ontology.

Biological process (BP), Cellular component (CC) and Molecular function (MF).

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Figure 2.

Evolution of the number of relations of the Gene Ontology (top left) and its Biological process (top right), Cellular component (bottom left) and Molecular function (bottom right) branches.

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Table 2.

Gene Ontology complexity variations.

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Table 3.

Proportions of classes for the three Gene Ontology branches.

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Table 4.

Proportions of relations for the three Gene Ontology branches.

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Figure 3.

Evolution of the average degree of the nodes of the three branches of the Gene Ontology.

Biological process (BP), Cellular component (CC) and Molecular function (MF).

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Figure 4.

Contributions of the is a, part of and regulates relations to a node's average degree for the Gene Ontology (top left) and its three branches Biological process (top right), Cellular component (bottom left) and Molecular function (bottom right).

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Figure 5.

Variations of the proportion of leaves for the Gene Ontology three branches.

Biological process (BP), Cellular component (CC) and Molecular function (MF).

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Figure 6.

Variations of the average height of the nodes from the Gene Ontology: together (top left), Biological process (top right), Cellular component (bottom left) and Molecular function (bottom right).

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Figure 7.

Variations of the average depth of the nodes from the Gene Ontology: together (top left), Biological process (top right), Cellular component (bottom left) and Molecular function (bottom right).

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Table 5.

Simulated evolution of the three Gene Ontology branches between February and March 2010.

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Figure 8.

Proportion of leaves for the fifty simulated ontologies, compared to the value for the March 2010 version of the Gene Ontology (red line).

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Figure 9.

Average classes' heights for the fifty simulated ontologies, compared to the value for the March 2010 version of the Gene Ontology (red line).

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Figure 10.

Average classes' depths for the fifty simulated ontologies, compared to the value for the March 2010 version of the Gene Ontology (red line).

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Table 6.

Comparison of the fifty randomly enriched ontologies with the March 2010 version of Gene Ontology.

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