Figure 1.
2D and 3D views of the average VMAT2 distribution in normal aging brain using 18F-FP(+)-DTBZ.
The sagittal view of the VMAT2 distribution in the section of right substantia nigra was displayed in (A) with the three lines indicating three different 2D transverse views as illustrated in (B), (C) and (D) at the level of striatum, NAc, and brain stem, respectively. The 3D visualizations of subcortical VMAT2 binding were illustrated in (E) and also at the views of (F) posterior, (G) right lateral, and (H) anterior with corresponding VOI.
Table 1.
Regional mean VMAT2 uptake.
Figure 2.
The mean regional SUR value and percentage SUR normalized to that of anterior putamen.
Two dash lines indicated levels of 0% (lower) and 5% (upper) SUR to the anterior putamen, respectively. This clearly illustrated the distribution spectrum of VMAT2 density in the regions of subcortex, cerebellum, cingulate and neocortex. Ct: Caudate, APt: Anterior Putamen, PPt: Posterior Putamen, SN: Substantia nigra, NAc: Nucleus accumbens, Rap: Raphe, Hy: Hypothalamus, Th: Thalamus, Hip: Hippocampus, Am: Amygdala, LC: Locus coeruleus, BS: Brain stem, Vem: Vermis, Cb: cerebellum cortex, SF: Superior Frontal, MiF: Middle Frontal, IF: Inferior Frontal, MeF: Medial Frontal, MA: Motor Area, Olf: Olfactory, SP: Superior Parietal, IP: Inferior Parietal, ST: Superior Temporal, MiT: Middle Temporal, IT: Inferior Temporal, SO: Superior Occipital, MO: Middle Occipital, AC: Anterior Cingulate, MC: Middle Cingulate, PC: Posterior Cingulate.