Figure 1.
General organization of the French AHB registry.
Figure 2.
General flow chart of the study.
Samples corresponding to notified AHB were classified according to both the values of HBc IgM and avidity index. Each biologically classified coherent case was thoroughly assessed for discrepancies with epidemiological and clinical information. When relevant information was not available physicians were interviewed on an individual basis.
Figure 3.
Distribution of HBV-VL (log10 IU/mL) according to disease course.
Black bars represent acute cases and gray bars anti-HBc IgM positive chronic cases and open bars anti-HBc IgM negative chronic cases.
Figure 4.
Phylogenetic tree obtained from 92 full length sequences.
The evolutionary history was inferred using the Neighbor-Joining method with a bootstrap test (500 replicates); bootstrap values are shown next to the branches. Sequences from 60 acute cases (black dots) and 24 chronic cases (open dot) and 8 reference sequences (grey triangles) were analyzed.