Table 1.
Demographic and clinical characteristics of subjects.
Table 2.
The primer sequences of GAPDH, DRD2 and DAT.
Figure 1.
Standard curves of GAPDH, DAT1 and DRD2 mRNA.
The standard curves of real-time PCR of GAPDH, DAT1 and DRD2 cDNA diluted in gradient 10-fold showed a good linear relationship. ▴:DAT, R2 = 0.994, y = 3.4844x+19.165; ♦:DRD2, R2 = 0.998, y = 4.5613x+16.226; ▪:GAPDH, R2 = 0.998, y = 3.5773x+18.880; Ct value: Cycle threshold value; LgC0: Logarithm of the initial concentration.
Figure 2.
DAT and DRD2 mRNA levels between the three groups.
DAT mRNA levels of the chronic schizophrenia patients were significantly higher than those in the control group (MS interclass = 0.198, p = 0.005), No significant difference was found in DRD2 mRNA levels between the three groups. ▪:DAT; ♦:DRD2.
Table 3.
Comparisons of DAT and DRD2 mRNA levels between the three groups (Mean±SD).
Figure 3.
Relationship between DRD2 mRNA levels and positive symptom points of PANSS in acute patients.
Spearman’s correlation analysis was chosen to find the significant relationship between the mRNA levels of DRD2 and positive symptom points of the PANSS score (r = 0.443, p = 0.044).
Table 4.
Correlation analysis between DAT and DRD2 mRNA levels and PANSS scores in schizophrenia patients (r value).
Table 5.
Influence of clinical factors on DAT and DRD2 mRNA levels.