Figure 1.
Synopsys of the exploratory study studying the relative impact of the pathophysiological conditions (ZDF (fa/+) and ZDF (fa/fa) rats) on the natural carbon isotopic abundance (δ13C) for individual metabolites measured in plasma, in breath and liver tissue samples by isotope ratio mass spectrometry.
Figure 2.
Schematic representation of the variation of carbon isotopic abundance (expressed in δ13C, ‰) of plasma glucose, plasma lipids in ZDF (fa/+) and ZDF (fa/fa) rats.
All the data were significantly different between both groups except for stearic acid (indicated by ‘#’).
Figure 3.
Principal component analysis (PCA) score plots of isotopic abundance of plasma metabolites measured by isotope ratio mass spectrometers (i.e. glucose, palmitic, oleic, stearic, linolenic and arachidonic acids) between ZDF (fa/+) and ZDF (fa/fa) rats.
Red dots are for ZDF (fa/+) whereas green ones stand for ZDF (fa/fa) rats. Letters are the identification code of the rat. Based on the PCA, there is a clear separation of both groups along PC1 and PC3, confirming that there is an isotopic signature at natural abundance that separates ZDF (fa/+) and ZDF (fa/fa) rats.