Figure 1.
Drawing of structure of vaginal mucosa.
This shows the gel layer over the epithelial surface. The small red circles are drug molecules. This view is the lower half of the complete side view of the lumen of the vaginal canal. A bilaterally symmetrical set of layers exists above those shown here.
Table 1.
Standard values of parameters used in the model.
Figure 4.
Ratio of drug concentration in the stromal layer to concentration in a simulated biopsy.
Standard conditions for gel and stromal thickness. This shows effects of differences in epithelial and biopsy thicknesses.
Figure 2.
Spatial concentration profiles of Tenofovir.
Standard conditions for gel, epithelial and stromal thicknesses. These are at different times in the half space between the centerline of the gel compartment layer and the epithelial and stromal layers.
Figure 3.
Average concentrations in different compartments vs. time.
Standard conditions for gel, epithelial and stromal thicknesses. These are spatial averages through the depths of the compartments. The simulated biopsy is the spatial average of combined epithelial and stromal compartments.
Table 2.
Summary pharmacokinetic parameters from computations by model for single application of 4.
Table 3.
Summary pharmacokinetic parameters in the epithelium and stroma with varying epithelial thickness (he).