Table 1.
Association of the 27 SNPs in the two-stage association study for AIS in Japanese.
Table 2.
Association of rs12946942 with severe AIS in Japanese and Chinese populations.
Figure 1.
Linkage disequilibrium (LD) map and P-value plot of the severe adolescent idiopathic scoliosis susceptibility locus at chromosome 17q24.3.
Top panel: The association results shown as – log10 of minimum P values in allele, recessive and dominant models and a focus view of the 130-kb LD block including rs12946942. All SNPs are analyzed in GWAS. Two vertical lines in this graph indicate the range of the LD block. rs12946942 is boxed. Middle panel: The ∼2 Mb LD map (D') around rs12946942 is shown using loci with MAF >0.10 from Phase II HapMap (release 24) JPT individuals. LD score: (dark red) LOD >2, D' = 1; (light red) LOD >2, D'<1; (blue) LOD <2, D' = 1; (white) LOD <2, D'<1. Bottom panel: The position of rs12946942 and the two candidate genes (KCNJ2 and SOX9) on chromosome (Chr.) 17.