Figure 1.
Pharmacokinetics of rhEPO-Fc with single and repeated injections.
Mean serum rhEPO-Fc concentration versus time after single subcutaneous injection in rhesus monkeys (Fig. 1A), rats (Fig. 1B) and repeated subcutaneous injections in rhesus monkeys (Fig. 1C) were plotted. Data were mean±SD for six rhesus monkeys or twelve rats per group.
Table 1.
Pharmacokinetic parameters of rhEPO-Fc following single subcutaneous injection in rhesus monkeys and rats.
Figure 2.
rhEPO-Fc attenuated anemia induced by irradiation in mice.
Blood samples were taken at day 0, 3, 7, 9, 13, 20, 27 and 34 to determine RBC (Fig. 2A), hemoglobin (Fig. 2B), hematocrit (Fig. 2C), and reticulocyte (Fig. 2D). Data were presented as Mean±SD.
Figure 3.
rhEPO-Fc attenuated anemia induced by partial renal ablation in rats.
Blood samples were collected at the indicated time points (0–4 week, and additional two weeks after the treatment ended). RBC (Fig. 3A), hemoglobin (Fig. 3B), hematocrit (Fig. 3C), reticulocyte (Fig. 3D) and BUN (Fig. 3E) were shown. Data were presented as Mean±SD.
Figure 4.
rhEPO-Fc attenuated anemia induced by cyclophosphamide in rhesus monkeys.
Blood samples were collected at 0–49 days during treatments and additional 2 times weekly after the treatment ended. RBC (Fig. 4A), hemoglobin (Fig. 4B), hematocrit (Fig. 4C), reticulocyte (Fig. 4D), leukocyte (Fig. 4E) and blood platelet (Fig. 4F) were determined. Data were presented as Mean±SD.