Table 1.
Characteristics of the databases in the EU-ADR network.
Figure 1.
Three-tier triage system (detection, filtering, and substantiation) for detecting ‘prime suspects’.
Figure 2.
Schematic representation of the process of substantiation of suspected drug-induced adverse events via proteins (A) and via pathways (B).
(From Bauer-Mehren A, van Mulligen EM, Avillach P, Carrascosa Mdel C, Garcia-Serna R, et al. (2012) Automatic filtering and substantiation of drug safety signals. PLoS Comput Biol 8: e1002457. Reproduced with permission from the authors).
Table 2.
Drugs potentially associated with acute myocardial infarction†.
Table 3.
Table 3. ‘Prime suspects’: drugs potentially associated with increased risk of acute myocardial infarction which passed the filtering (i.e. novelty) and substantiation (i.e. biological plausibility) criteria.
Figure 3.
Central role of histamine in drug-induced acute myocardial infarction via Kounis syndrome.
Aside from its direct vasoconstricting and thrombus-generating effects, histamine also potentiates the platelet aggregating response to adrenaline (dotted outline).