Table 1.
Clinical features and autoantibody profile in 200 SLE patients.
Figure 1.
Distribution of anti-dsDNA IgG, IgM and IgA isotype values in SLE and controls.
Footnotes: IU: international units; IgG: immunoglobulins class G; IgM: immunoglobulins class M; IgA: immunoglobulins A; anti-dsDNA: antibodies against double stranded DNA; SLE: systemic lupus erythematosus; IIM: idiopathic inflammatory myopathies; RA: rheumatoid arthritis; PA: psoriatic arthritis; SjS: Sjögren’s syndrome; SSc: systemic sclerosis; ID: infectious diseases; HS: healthy subjects; c.o. = cut off; SP: specificity.
Table 2.
Prevalence of different anti-dsDNA antibody isotypes in 200 SLE patients.
Figure 2.
Comparison of anti-dsDNA IgG, IgM and IgA autoantibody levels in SLE patients with and without kidney involvement.
Median serum values are illustrated (horizontal lines). Median serum values (horizontal lines) of IgG, IgM and IgA anti-dsDNA resulted 171.0±125.1 IU/mL (range: 2.8–2046); 59.5±78.8 U/mL (range: 1.0–503), 122.5±122.8 U/mL (range: 1.0–1012) in patients with kidney involvement, and 131±123.7 IU/mL (range: 3.0−1018), 76.1±100.5 U/mL (range: 2.6–718), 49.8±84.7 U/mL (range: 1.0–382) in patients without kidney involvement, respectively. Footnotes: IU: international units; IgG: immunoglobulins class G; IgM: immunoglobulins class M; IgA: immunoglobulins A; anti-dsDNA: antibodies against double stranded DNA.
Figure 3.
Anti-dsDNA IgG/IgM and IgA/IgM ratios in SLE patients with (10.8±23.8, range 0.25−160 and 9.36±7.3, range 0.4–28, respectively) and without (4.6±7.8, range 0.18–22.6 and 1.51±1.8, range 0.01–10.3, respectively) kidney involvement.
Median serum values are shown (horizontal lines). Footnotes: IgG: immunoglobulins class G; IgM: immunoglobulins class M; anti-dsDNA: antibodies against double stranded DNA.
Figure 4.
IgG, IgM and IgA anti-dsDNA isotypes levels and IgG/IgM anti-dsDNA ratio in patients with ECLAM score ≤4 (138.8±124.6 IU/mL, range: 2.8–901; 72.7±97.6 U/mL, range: 1.0–1012; 72.8±96.6 U/mL, range: 1.0−543; and 6.25±10.6, range 0.18–83, respectively) and with ECLAM score >4 (175±122.4 IU/mL, range: 2.9–2046; 58.9 U/mL ±74.6, range 1.0–618; 124.6±124.7 U/mL, range 1.0–1018, and 10.7±14.9, range 0.32–103, respectively).
Association between IgG, IgM and IgA anti-dsDNA isotypes and IgG/IgM anti-dsDNA ratio and the ECLAM score. Median serum values are shown (horizontal lines). Footnotes: IU: international units; IgG: immunoglobulins class G; IgM: immunoglobulins class M; IgA: immunoglobulins A; anti-dsDNA: antibodies against double stranded DNA; ECLAM: European Consensus Lupus Activity Measurement.