Table 1.
Clinical characteristics of study population.
Figure 2.
Combined effects of increasing numbers of isolated postprandial hyperglycaemia-associated risk alleles from TCF7L2, CDKAL1, KCNQ1, PRC1, TP53INP1 and GCKR.
A: The isolated postprandial hyperglycaemia-associated risk allele distribution in controls, participants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia. Each additional risk allele increased the risk of isolated postprandial hyperglycaemia by 1.19-fold (p<0.0001) (B) but not the risk of isolated fasting hyperglycaemia (C). OR and 95% CI were plotted on the y-axis for the corresponding number of risk alleles on the x-axis (black circles = risk of isolated fasting hyperglycaemia; white circles = risk of isolated postprandial hyperglycaemia). B: Participants harboring eight or more risk alleles had a 2.31-fold increased risk for isolated postprandial hyperglycaemia (p<0.0001) compared with the reference group. C: However, risk for isolated fasting hyperglycaemia was not increased as risk allele number increasing. IFH, isolated fasting hyperglycemia; IPH, isolated postprandial hyperglycemia.
Table 2.
SNPs significantly associated with isolated fasting hyperglycemia in Hans.
Figure 1.
Combined effects of increasing numbers of isolated fasting hyperglycaemia-associated risk alleles for TCF7L2, CDKN2BAS, KCNQ1, FTO and GCKR.
A: The isolated fasting hyperglycaemia-associated risk allele distribution in controls, participants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia. Each additional risk allele increased the risk of isolated fasting hyperglycaemia by 1.24-fold (p<0.0001) (B) but not the risk of isolated postprandial hyperglycaemia (C). OR and 95% CI plotted on the y-axis for the corresponding number of risk alleles on the x-axis (black circles = risk of isolated fasting hyperglycaemia; white circles = risk of isolated postprandial hyperglycaemia). B: Participants harboring five or more risk alleles had a 2.23-fold increased risk for isolated fasting hyperglycaemia (p<0.0001) compared with the reference group. C: However, risk for isolated postprandial hyperglycaemia was not increased as risk allele number increased. IFH, isolated fasting hyperglycemia; IPH, isolated postprandial hyperglycemia.
Table 3.
SNPs significantly associated with isolated postprandial hyperglycemia in Hans.
Table 4.
SNPs showed significant differences in risk allele frequency and genotype distribution between isolated fasting hyperglycemia and isolated postprandial hyperglycemia.