Table 1.
Characteristics of patients with TRD or TSD and HS.
Figure 1.
Statistical maps showing VMHC differences in different brain regions between studied groups.
Red denotes VMHC differences in the ANOVA analyses and the yellow/red color bar indicates the F value from the ANOVA analyses. Blue denotes lower VMHC and the green/blue color bars indicate the T value from post hoc analysis between compared groups. Of note, the two-sample t-test results within a mask showed significant group differences in the ANOVA analysis. VMHC = voxel-mirrored homotopic connectivity, TRD = treatment-resistant depression, TSD = treatment-sensitive depression, HS = healthy subjects.
Table 2.
Significant differences in VMHC values between groups.
Figure 2.
Statistical maps showing seed-based FC differences between subject groups (seed: the left calcarine cortex).
Red denotes FC differences in the ANOVA analyses and the color bar indicate the F value from the ANOVA analyses. Blue denotes lower FC and the color bars indicate the T value from post hoc analysis between each pair of groups. Of note, the two-sample t-test results within a mask showed significant group differences in the ANOVA analysis. FC = functional connectivity, TRD = treatment-resistant depression, TSD = treatment-sensitive depression, HS = healthy subjects.
Figure 3.
Statistical maps showing seed-based FC differences between subject groups (seed: the right calcarine cortex).
Red denotes FC differences in the ANOVA analyses and the color bar indicate the F value from the ANOVA analyses. Red and blue denote higher and lower FC respectively and the color bars indicate the T value from post hoc analysis between each pair of groups. Of note, the two-sample t-test results within a mask showed significant group differences in the ANOVA analysis. FC = functional connectivity, TRD = treatment-resistant depression, TSD = treatment-sensitive depression, HS = healthy subjects.
Table 3.
Significant differences in seed-based resting-state FC between groups.
Figure 4.
Bar plots representing the mean (and standard error) VMHC value of the calcarine cortex.
Significant differences found between the TRD group and the TSD group or the HS group (TRD vs TSD: p<0.001; TRD vs HS: p<0.01). VMHC = voxel-mirrored homotopic connectivity, TRD = treatment-resistant depression, TSD = treatment-sensitive depression, HS = healthy subjects.
Figure 5.
Receiver operating characteristic (ROC) curves by using the mean VMHC value in the calcarine cortex.
A. Separating TRD from TSD; B. Separating TRD from HS; C. Separating TSD from HS. VMHC = voxel-mirrored homotopic connectivity, TRD = treatment-resistant depression, TSD = treatment-sensitive depression, HS = healthy subjects.
Table 4.
ROC analysis for differentiating different studied groups.