Table 1.
Characteristics of subjects in each group.
Figure 1.
(A) On the left side of this panel, we illustrate the triangulated surface of the template hippocampus and the manually defined seven points (in red). On the right side, the seven points drawn on the subject’s hippocampus are shown in blue, and the ICP algorithm is illustrated which minimises the sum of distances (di) between the red and blue points. (B) Illustration of the deformation field mapping onto the triangulated hippocampal surface resulting in different colours for inward (blue) and outward (orange) deformation.
Figure 2.
Mean atrophy rate in mm/year for the left and right hippocampi in patients with AD (A), MCI (B) and controls (C). On the right hippocampus, projected borders of subfields CA1, CA2–3, dentate gyrus (DG) and subiculum (Sub) are indicated with grey outlines.
Table 2.
Summary of hippocampal volumetry.
Figure 3.
Statistical maps showing the -log(p-values) for significant (p0.05 corr.) atrophy rates for the left and right hippocampi in patients with AD (A), MCI (B) and controls (C). Significance level (p
0.05 corr.) is indicated in the colour bar.
Figure 4.
Statistical maps of atrophy rate differences among groups.
Statistical maps showing significantly higher atrophy rate in AD versus control (A), MCI versus control (B), and AD versus MCI (C). Significance level (p0.05 corr.) is indicated in the colour bar.
Figure 5.
ROI analysis of atrophy rates in progressive and stable MCI.
Bar plots of atrophy rates in the left and right hippocampal ROIs (shown in Figure 4) for pMCI (n = 39) and sMCI (n = 44). *: p0.05, **: p
0.001 Bonferroni adjusted p-values.