Figure 1.
Timeline of imaging protocol.
Figure 2.
Total brain volume for each age group/scan type.
Figure 3.
Pearson’s correlation between brain volume, brain weight and body weight.
Figure 4.
Volume of selected regions as a function of age and scan type.
Table 1.
Descriptive statistics for volumetric measurements for each age group and scan type.
Figure 5.
Ventricles in Live and Postmortem brains.
Sagittal sections that highlight the lateral ventricles are shown for a live and Postmortem-2 brain scan of a P80 young adult animal. Ventricular spaces are highlighted in red. Note the post mortem image shows clear brain regional morphology, whereas the live image shows discretization artifacts in the highlights. These differences in image quality would be expected to improve segmentation accuracy and quantification of ventricles similar to other brain regions. However, the ventricles are fluid-filled spaces that are more likely to be altered by post mortem procedures. Although our ventricular volumes were not statistically different in live vs post mortem comparisons, at each age studied there is an apparent trend of reduced volumes from live to Postmortem-1 and Postmortem-2, which suggests post mortem ventricular values should be interpreted with particular caution compared to the other brain regions of interest.
Figure 6.
(A) visual assessment. (B) intensity profile across the corpus callosum.
Figure 7.
Signal-to-noise ratio.