Table 1.
Characteristics of participants in three cohorts.
Figure 1.
A cross-sectional study of the AMH levels across the adult lifespan of males.
The levels of serum AMH in 205 community dwelling men (Otago cohort) are illustrated. A: each dot represented an individual. B: the geometric mean and 95% confidence interval is indicated for various age groups. The levels of AMH in the older men (80–93 years) were significantly less than those in the younger men (20–40 years) (p = 0.006). To convert pmol/L of AMH to ng/ml, divide by 7.14.
Figure 2.
A cross-sectional study of the serum InhB levels across the adult lifespan of males.
The levels of serum InhB in 205 community dwelling men (Otago cohort) are illustrated. A: each dot represented an individual. B: the geometric mean and 95% confidence interval is indicated for various age groups. The levels of Inhibin B in the older men (80–93 years) were significantly less than those in the younger men (20–40 years) (p<0.001).
Figure 3.
A cross-sectional study of the balance of Sertoli cell hormones across the lifespan of men.
The relationship between AMH and InhB in 205 community dwelling men (Otago cohort) is illustrated. A: The ratio of the hormones across the age spectrum was calculated as described in the Methods. B: Each open circle represents an individual. The linear regression between AMH and Inhibin B was r = 0.48 (p<0.001).
Figure 4.
A comparison of Sertoli hormone levels between 3 New Zealand cohorts.
The Otago cohort (205 community dwelling men in Dunedin) is illustrated with brown open circles; the Vascular cohort (153 men in Dunedin selected for their absence of cardiovascular disease) with red open circles and the LiLACS NZ cohort (257 men from a distinct geographical area to Otago) with green open circles. Each circle represents an individual. A: The Vascular cohort had a higher mean AMH value than the aged matched portion of Otago cohort (p<0.001), but were not different to the younger subset (20–50 years), p = 0.35. B: The vascular cohort had similar InhB levels to the aged matched subset of the Otago cohort (p = 0.13), but lower than levels than the younger Otago subset (p<0.001). C: The LiLACS NZ cohort showed similar aged related decline in both A: AMH (p = 0.08) and D: InhB (p = 0.76) when compared to the aged matched subset of the Otago cohort, whilst being different to the younger subset for both hormones, p<0.001 (20–50 years).
Figure 5.
The ratio of AMH and InhB in the cohorts of community dwelling men.
The Otago cohort is represented by brown open circles (n = 205), the vascular cohort by red open circles (n = 153) and the LiLACS NZ cohort by green open circles (n = 257). Each open circle represents an individual. An increasing divergence was seen in the older age groups. The vascular cohort had an AMH bias. The ratio of the hormones across the age spectrum was calculated as described in the Methods.