Figure 1.
Number of participants and mean plasma 25-hydroxyvitamin D, 25(OH)D in subgroups of age-related macular degeneration.
Participants were categorized into subgroups after a thorough retinal examination. Please note that when comparing vitamin D status in patients in CARMS 5 with or without subretinal fibrosis, 46 previously treated patients with neovascular AMD were excluded from analysis (denoted by asterix).
Table 1.
Sociodemographic, lifestyle and clinical characteristics of participants (n = 178).
Figure 2.
25-hydroxyvitamin D in patients in CARMS 5 with or without subretinal fibrosis.
Patients with subretinal fibrosis had significantly lower plasma 25-hydroxyvitamin D concentrations compared to patients without subretinal fibrosis (p<0.001). Horizontal lines represent means.
Figure 3.
Subretinal fibrosis status in patients with vitamin D insufficiency or sufficiency.
Patients without subretinal fibrosis (light filling) were more likely to be vitamin D sufficient compared to those with subretinal fibrosis (dark filling) who were more likely to be deficient (p = 0.006, Pearson's Chi-square test). Vitamin D insufficiency was defined as 25-hydroxyvitamin D≤50 nmol/L and sufficiency was defined as >50 nmol/L.
Table 2.
Sociodemographics, lifestyle and clinical chacteristics for treatment-naïve patients in CARMS 5 with or without fibrosis.
Table 3.
Number of patients with or without subretinal fibrosis according to season.
Table 4.
Genotype frequencies of participants.