Figure 1.
Structure of (a) amsacrine (m-Amsa) and (b) o-Amsa.
Figure 2.
Stacked view of FTIR spectra of ctDNA (a) and its complexes with amsacrine at different molar ratios (r) of 1/50 (b), 1/20 (c) and 1/10(d).
Figure 3.
Overlaid view of second derivative spectra of ctDNA and duplexes with their complexes of amsacrine at molar ratio of 1/10 (drug/nucleotide).
Panel 1: ctDNA (blue) and complex (red), Panel 2: (AAAAAAAAAAAA)2 (blue) and complex (red) (b), Panel 3: (ATATATATATAT)2 (blue) and complex (red), Panel 4: (TTAATTAATTAA)2 (blue) and complex (red), Panel 5: (AGAGCAACAGAG)2 (blue) and complex (red), Panel 6: (AGAGACCAGAGA)2 (blue) and complex (red).
Figure 4.
Close-up view of the FTIR spectra of ctDNA and duplexes with their complexes of amsacrine at 1/10 molar ratio (drug/nucleotide) in the 950-700 cm−1 spectral range.
Panel 1: ctDNA (a) and complex (b), Panel 2: (AAAAAAAAAAAA)2 duplex (a) and complex (b), Panel 3: (ATATATATATAT)2 duplex (a) and complex (b), Panel 4: (TTAATTAATTAA)2 duplex (a) and complex (b), Panel 5: (AGAGCAACAGAG)2 duplex (a) and complex (b), Panel 6: (AGAGACCAGAGA)2 duplex (a) and complex (b).
Figure 5.
Stacked view of FTIR spectra of (AAAAAAAAAAAA)2 duplex (a) and its complexes with amsacrine at different molar ratios (r) of 1/50 (b), 1/20 (c) and 1/10 (d).
Figure 6.
Stacked view of FTIR spectra of (ATATATATATAT)2 duplex (a) and its complexes with amsacrine at different molar ratios (r) of 1/50 (b), 1/20 (c) and 1/10 (d).
Figure 7.
Stacked view of FTIR spectra of (TTAATTAATTAA)2 duplex (a) and its complexes with amsacrine at different molar ratios (r) of 1/50 (b), 1/20 (c) and 1/10 (d).
Figure 8.
Stacked view of FTIR spectra of (AGAGCAACAGAG)2 duplex (a) and its complexes with amsacrine at different molar ratios (r) of 1/50 (b), 1/20 (c) and 1/10 (d).
Figure 9.
Stacked view of FTIR spectra of (AGAGACCAGAGA)2 duplex (a) and its complexes with amsacrine at different molar ratios (r) of 1/50 (b), 1/20 (c) and 1/10 (d).