Figure 1.
Scatter plot for 977 pairs of total lymphocyte count (TLC) and CD4 cell count.
The lower circle dots are for 725 pairs of TLC (median [interquartile], 1370 [1025–1760] cells/mm3) and CD4 cell count of less than 350 cells/mm3. The middle diamond dots are for 124 pairs of TLC (median [interquartile], 1885 [1500–2355] cells/mm3) and CD4 cell count of between 350 cells/mm3 and 500 cells/mm3. The upper triangle dots are for 128 pairs of TLC (median [interquartile], 2222 [1840–2698] cells/mm3) and CD4 cell count of greater than 500 cells/mm3.
Table 1.
Characteristics of the 977 HIV-infected patients included in the study.
Figure 2.
Receiver operating characteristic (ROC) curves for TLC thresholds predicting a CD4 cell count <350 cells/mm3 and a CD4 cell count <500 cells/mm3.
Areas under ROC curves (AUCs) were 0.80 and 0.82, respectively.D.
Table 2.
Data from articles included in the literature review.
Figure 3.
Forest plots of eight studies on a TLC threshold of 1500 cells/mm3 for predicting a CD4 cell count <350 cells/mm3.
95% confidence intervals (CIs) of sensitivity and specificity are in parentheses. The figure shows the estimated sensitivity and specificity of the study (square) with its 95% confidence interval (horizontal line). The pooled sensitivity and specificity were 0.68 (95 CI%, 0.56–0.78) and 0.81(95% CI, 0.67–0.90), respectively.
Figure 4.
Summary receiver operating characteristic (SROC) plot of eight studies on a TLC threshold of 1500 cells/mm3 for predicting a CD4 cell count <350 cells/mm3.
The area under the SROC curve (the solid line) is 0.80; the larger dot is the pooled value for sensitivity and specificity (0.68 and 0.81, respectively); the ellipse around the larger dot represents the 95% confidence interval around the summary estimates.
Table 3.
Pooled effects for predicting a CD4 cell count <350 cells/mm3 by using different TLC thresholds.