Figure 1.
Melanoma in association with a nevus in overview (A) and closeup (B).
Immunohistochemically stained in (C) with the BRAFV600E-mutation specific antibody VE1. Benign(D) and malignant(F) parts of the tumor in closeup. E&G show sequencing result of the corresponding cuts.
Figure 2.
Comparison of mutation status between paired tumor groups.
BRAFV600E-mutation status was evaluated by VE1-Immunohistochemistry and Sanger sequencing, NRASQ61 by Sanger sequencing alone. p-values denote two-tailed significance as measured by McNemar test.
Figure 3.
Representative tumor parts of nevi groups.
Melanoma associated nevi are more commonly strictly dermal and show less of the postulated features of so called "dysplastic" nevi.