Figure 1.
Flow diagram of patients screened and enrolled for the ARGISM-1 study.
Table 1.
Baseline characteristics and laboratory results in severe malaria patients.
Figure 2.
a. Profile of the systolic blood pressure of patients before, during and one hour after receiving L-arginine. Dotted lines indicate patients who received saline. L-arginine was infused between zero and eight hours. b. Profile of the diastolic blood pressure of patients before, during and one hour after receiving L-arginine. Dotted lines indicate patients who received saline.
Table 2.
Maximum change in parameters at any time during and up to one hour after L-arginine infusion.
Figure 3.
a. Profile of the venous potassium concentration of patients before, during and three hours after receiving L-arginine. Broken lines indicate patients with acute renal failure and dotted lines indicate patients who received saline. L-arginine was infused between zero and eight hours. b. Profile of the venous bicarbonate concentrations of patients before, during and three hours after receiving L-arginine. Broken lines indicate patients with acute renal failure and dotted lines indicate patients who received saline. c. Profile of the venous blood glucose concentrations of patients before, during and three hours after receiving L-arginine. Broken lines indicate patients with acute renal failure and dotted lines indicate patients who received saline. d. Profile of the venous blood chloride concentrations of patients before, during and three hours after receiving L-arginine. Broken lines indicate patients with acute renal failure and dotted lines indicate patients who received saline.
Figure 4.
RH-PAT index profile pre-infusion, one hour and eight hours after infusion of L-arginine.
Dotted lines indicate patients who received saline.
Figure 5.
Time-concentration curves for plasma L-arginine concentrations before and after infusion of 12 g L-arginine (solid line) or saline (broken line) for patients 1 to 5.
X-axis = time in hours, y-axis = L-arginine concentration in mg/L.
Table 3.
Pharmacokinetic parameter values estimated in the patients with severe malaria compared to those from moderately severe malaria [15].