Figure 1.
Dose response curves for various IC (A) or shape parameters,
(B).
Figure 2.
Dose response curves for viral replication of various HIV mutations at different EFV concentrations.
The HIV strain names are the same as in previous publication [11]. Dose response was determined as proportion reduction in HIV replication at a given EFV dose relative to HIV replication in the absence of EFV. Viral replication above 100% indicates that suboptimal doses of EFV potentiate the ability of the viral strain to replicate compared to the absence of EFV. The data used to generate figures is available upon request.
Figure 3.
The patterns of functions , (A); and
, (B); for different
values.
Table 1.
The value (standard deviation) of the monotonicity tests for the simulation study.
Table 2.
The average -values of the monotonicity test for the real data example.
Figure 4.
Solid line indicates the nonparametric model and dashed line indicates the sigmoidal model if it is available.
Table 3.
IC values estimated by using the nonparametric and the sigmoidal models for real datasets.