Figure 1.
X-ray diffraction data for salmeterol xinafoate (SX) and fluticasone propionate (FP).
Figure 2.
Representative SEM images of the sieved and placebo blended carrier material.
Mixing times for the placebo blends displayed are 420 and 600 minutes for the coarse and fine fraction, respectively.
Figure 3.
Representative SEM images of the salmeterol blend containing a coarse carrier at different mixing times.
Mixing times are given in minutes. Magnifications on the right hand side are taken from the images on the left hand side.
Figure 4.
Representative SEM images of the salmeterol blend containing a fine carrier at different mixing times.
Mixing times are given in minutes. Magnifications on the right hand side are taken from the images on the left hand side.
Figure 5.
Representative SEM images of the fluticasone blend containing a coarse carrier at different mixing times.
Mixing times are given in minutes. Magnifications on the right hand side are taken from the images on the left hand side.
Figure 6.
Representative SEM images of the fluticasone blend containing a fine carrier at different mixing times.
Mixing times are given in minutes. Magnifications on the right hand side are taken from the images on the left hand side.
Figure 7.
X50 from laser diffraction analysis of suspended drug particles after dissolution of the carrier material.
Y-error bars represent minimum and maximum values measured (n = 2).
Figure 8.
Change in apparent solubility of salmeterol during mixing with the coarse and fine lactose carrier.
The apparent solubility is represented by the absorption of the solution at 280 nm.
Figure 9.
Light microscopic images of suspended fluticasone films after dissolution of the lactose carrier.
Top: 1.48% fluticasone mixed with the fine carrier for 600 minutes, the scale bar represents 60 µm; bottom: 0.4% fluticasone mixed with the coarse carrier for 420 minutes, the scale bar represents 15 µm.
Figure 10.
Representative SEM images showing morphological changes to the drug particles occurring during mixing.
Top: the salmeterol (SX) and fluticasone (FP) starting materials; bottom: drug agglomerates on the fine carrier after a certain mixing time (in minutes).
Figure 11.
Drug detachment at 20 and 60 L/min as function of mixing time.
Y-error bars represent minimum and maximum values measured (n = 5).