Table 1.
Characteristics of patients and laryngeal lesions
Figure 1.
A patient with pathologically proven T1bN0M0 laryngeal carcinoma.
A: A lesion was only found in the right vocal cord, and another lesion in the left vocal cord was not found by laryngostroboscopy. B: Transverse T2-weighted MRI showed a tumor in the right vocal cord. C: DWI suggested lesions were in the bilateral vocal cords (b = 1000 s/mm2). D: Consequently, the corresponding ADC map revealed hypointense lesions in the bilateral cord (ADC = 1.05×10−3 mm2/s in the left vocal cord, ADC = 0.90×10−3 mm2/s in the right vocal cord).
Figure 2.
A patient with a pathologically proven laryngeal precancerous lesion.
A: A lesion in the left vocal cord was suspected to be laryngeal carcinoma by laryngostroboscopy. B: DWI suggested hyperintense lesions in the left vocal cords (b = 1000 s/mm2). C: The corresponding ADC map also revealed hyperintense lesions in the left cord (ADC = 2.01×10−3 mm2/s). These findings suggest that the lesion in the left vocal cord may be benign.
Figure 3.
A patient with pathologically proven laryngeal carcinoma in the left vocal cord and mild dysplasia in the right vocal cord.
A: Laryngostroboscopy showed a 5 × 6-mm mass in the left vocal cord and rough mucosa in the anterior right vocal cord suspected to be bilateral laryngeal carcinoma in the vocal cords. B: DWI-suggested lesions were identified in the bilateral vocal cords (b = 1000 s/mm2). C: Consequently, the corresponding ADC map reveals hypointense of lesions in the left vocal cord. (ADC = 1.26×10−3 mm2/s), and hyperintense of lesions in the right vocal cord(ADC = 1.67×10−3 mm2/s).
Figure 4.
A patient with pathologically proven laryngeal carcinoma in the left vocal cord.
A: A small superficial lesion in the left vocal cord was found by laryngostroboscopy. B: DWI suggested a lesion in the left vocal cord to be hyperintense. C: Consequently, the ADCs of both vocal cords were delineated (ADC = 1.40×10−3 mm2/s in the left vocal cord, ADC = 1.65×10−3 mm2/s in the right vocal cord). These findings suggest that the lesion in the left vocal cord may be malignant, and that in the right vocal cord may be benign.
Figure 5.
A: Box and whisker plots showing the ADC values of laryngeal carcinomas (LCs) and precancerous lesions (PLs). The ADC values were lower for patients with laryngeal carcinoma (mean 1.195±0.32×10−3 mm2/s) compared with those with laryngeal precancerous lesions (mean 1.780±0.32×10−3 mm2/s; P<0.001). B: Receiver operating characteristic (ROC) analysis showed that the area under the curve was 0.956, whereas the optimal threshold for the ADC was 1.455×10−3 mm2/s.