Figure 1.
Main metabolic routes of serotonin and dopamine to their phase I metabolites.
Table 1.
Validation results for all the compounds analyzed.
Figure 2.
Findings in the human brain microdialysis samples.
SRM ion chromatograms of A: standards (1 nM 5-HT and 5-HT-G, 5 nM DA-3-O-S and HVA-O-G, 100 nM HVA, 5-HIAA and 5-HIAA-S); B: a blank sample (Ringer’s solution); C: a human brain microdialysis sample from patient 1; D: a human brain microdialysis sample from patient 2.
Table 2.
Findings in the human brain microdialysis and the human cerebrospinal fluid samples.
Figure 3.
Findings in the human CSF samples.
SRM ion chromatograms of A: standards (0.5 nM 5-HT and 5-HT-S, 10 nM DA-4- and 3-O-S and 100 nM HVA, 5-HIAA and 5-HIAA-S); B: a blank sample (Ringer’s solution); C-F: ventricular cerebrospinal fluid samples from patients 3–6; G: lumbar cerebrospinal fluid sample pooled from several patients.