Figure 1.
Plot showing the study power of the selected SNPs in both (A) Australian (n = 232 cases and n = 288 controls) and (B) Nepalese (n = 106 cases and 204 controls) populations per-allele odds ratio.
X-axis represents relative risk (range from 1.0 to 2.4) and Y-axis the power in percentage. Minor allele frequencies of each SNP are presented in Table 1.
Table 1.
Minor allele frequencies (%) of SNPs, and p-value adjusted for age and sex for the Australian and Nepalese cohorts with the odds ratio (95% CI).
Table 2.
Association results of previously reported PACG SNPs after adjustment for population stratification under a Cocrhan-Mantel-Haenszel test, showing p-value under the additive model, meta-analysis using the adjusted odds ratio and standard error of the point estimate, accompanied by p-het and I-squared index.
Figure 2.
Forest plot showing the odds ratio and 95% CI of the four typed SNPs in the Australian, the Nepalese, the combined analysis and the meta-analysis results of previous GWAS.
The risk estimate axis ranges from 0.5 to 4.0.