Table 1.
Demographic data of OCD and HC.
Figure 1.
Four regions, mainly in the ACC, the MCC, the brainstem and the cerebellum, showed increased fALFF in subjects with OCD compared to the HC group (yellow color, small letters a to d). Four regions, located in the PCC, the IPL, the MFC and the precentral lobe separately, showed decreased fALFF in OCD (blue color, small letters e to h). Abbreviations: OCD, obsessive compulsive disorder; HC, healthy control; ACC, anterior cingulate cortex; MCC, midcingulate cortex; PCC, posterior cingulate cortex; IPL, inferior parietal lobe; MFC, middle frontal cortex.
Figure 2.
Abnormal FC of the ACC and the PCC in OCD.
Compared with controls, the FC of the ACC and the PCC showed different patterns in OCD. For the ACC (yellow color), significantly increased FC with the MPFC, the brainstem, and the left SMA (red color) and decreased FC with the OFG, the DLPFC and the temporal lobe (blue color) were found in OCD group (A). For the PCC (light blue color), the results showed increased FC with the right OFG, the DLPFC and the ACC and decreased FC with the brainstem in OCD patients (B). Abbreviations: DLPFC, dorsolateral prefrontal cortex; OFG, orbital frontal gyrus; SMA, supplementary motor area.
Figure 3.
Abnormal FC of the ACC and the PCC correlated with symptom severity of OCD.
Panel A shows the networks that comprise the PCC, while panel B shows the networks that comprise the ACC. A negative correlation between YBOCS scores and FC magnitudes of the precuneus/PCC was found (A); in contrast, a positive correlation between YBOCS scores and FC magnitudes was found in the ACC (B). Abbreviations: YBOCS, Yale–Brown Obsessive Compulsive Scale.