Table 1.
Demographic Characteristics of Patients With MCI.
Figure 1.
PIB-PET DVR images from 4 representative MCI converters and stable patients with (+) and without amyloid deposition (−) at baseline.
Figure 2.
The cortical PIB DVR values in PIB-positive MCI converters (closed circles, n = 29), PIB-negative MCI converter (open circles, n = 1), PIB-positive stable MCI patients (closed triangles, n = 22), and PIB-negative stable MCI patients (open triangles, n = 16) at baseline and follow-up.
Data are presented as mean ± SD. *Statistically significant difference from the PIB-negative stable MCI patients by multiple comparisons post hoc tests (p<0.01).
Figure 3.
Regional FDG SUVR values in the lateral temporal cortex, frontal cortex, precuneus and parietal cortex of MCI converters (closed circles, n = 30) and stable patients (open circles, n = 38) at baseline.
Data are presented as means ± SD. *Statistically significant difference from the stable patients by multiple comparisons post hoc tests (p<0.05).
Figure 4.
Scatter plot of the relationship between cortical PIB DVR and FDG SUVR values in individual MCI converters (closed circles, n = 30) and stable patients (open circles, n = 38).
The horizontal dotted line indicates the greatest value of PIB DVR (≥1.49). The vertical dotted line indicates the lower value of FDG SUVR (≤0.99).
Table 2.
Sensitivity and specificity of positive Aβ and/or FDG PET biomarkers for MCI due to AD in individual MCI patients.