Figure 1.
Flow chart on cases of allopurinol exposure and pregnancy (FUP = Follow-up).
Figure 2.
Diagram summarizing pregnancy interval of allopurinol exposure, week at first contact and outcome of 31 prospectively ascertained pregnancies.
Table 1.
Maternal characteristics and obstetrical history of allopurinol exposed women.
Figure 3.
Estimation of cumulative incidences using survival analysis technique.
Probability of spontaneous abortion was 11% (95%-confidence interval (CI) 3–40), ETOP 9% (95%-CI 2–32), and live birth 80% (95%-CI 60–85).
Figure 4.
Bars in colors give the proportions of newborns by percentiles. Grey bars represent the proportion of newborn in the German Perinatal Project general population [10] in each percentile category.
Table 2.
Child characteristics.
Table 3.
Summary of congenital anomalies after first trimester exposure with allopurinol.
Table 4.
Clinical features of the patient described by Kozenko et al. [6] and our patient # 31.