Figure 1.
Flow Diagram for included and excluded studies.
Table 1.
Trial characteristics.
Table 2.
Main characteristics of studies included.
Table 3.
Main treatment effects and progression of patients with mCRC.
Figure 2.
Forest plots of ORR, PFS, and OS in unselected patients in metastatic colorectal cancer.
(A) RR for overall response rate (BRAF Mutant vs BRAF WT), random-effects model; (B) HR for progression free survival (BRAF WT vs BRAF Mutant), random-effects model; (C) HR for overall survival (BRAF WT vs BRAF Mutant), fixed-effects model.
Figure 3.
Forest plots of ORR, PFS and OS in KRAS Wild-type patients.
(A) RR for overall response rate (BRAF Mutant vs BRAF WT), fixed-effects model; (B) HR for progression free survival (BRAF WT vs BRAF Mutant), random-effects model; (C) HR for overall survival (BRAF WT vs BRAF Mutant), fixed-effects model.