Figure 1.
(A) pure standard of 5 ng/ml N-desmethyl-olanzapine, 5 ng/ml olanzapine and 80 ng/ml clozapine dissolved in mobile phase without extraction; (B) pure standard of 20 ng/ml N-desmethyl-olanzapine, 20 ng/ml olanzapine and 80 ng/ml clozapine dissolved in mobile phase without extraction; (C) blank extracted plasma sample; (D) Extracted plasma sample spiked with 5 ng/ml N-desmethyl-olanzapine, 5 ng/ml olanzapine and 80 ng/ml clozapine; (E) Extracted plasma sample spiked with 20 ng/ml N-desmethyl-olanzapine, 20 ng/ml olanzapine and 80 ng/ml clozapine.
Table 1.
Precision and accuracy for the determination of olanzapine and N-desmethyl-olanzapine in spiked plasma.
Figure 2.
Chromatogram of a SPE extracted serum sample from a patient who received 20 mg of OLZ daily. DMO, N-Desmethyl-olanzapine; OLZ, olanzapine; CLZ, clozapine.
Table 2.
Summary of patients’ demographic and metabolic characteristics.
Table 3.
Correlations of olanzapine or desmethylolanzapine to individuals’ metabolic parameters in patients with schizophrenia (n = 48).