Table 1.
Genetic findings detected in GOM-positive patients suspected to have CADASIL.
Figure 1.
Transmission electron microscopic image of a muscle biopsy from a GOM-positive patient (#1).
Smooth muscle cells in the tunica media of a small artery. The cytoplasm, which in one cell includes the nucleus, contains the characteristic organelles of smooth muscle cells: filaments (f) and dense bodies (db). Cells are surrounded by the basal membrane (bm). Several GOM deposits can be seen outside the cells, often in cell membrane invaginations. The small clumps of electron dense material (arrows) between cells and included in collagen (C) are not GOM but debris, probably deriving from cell degeneration. Scale bar = 0.6 µm.
Figure 2.
Transmission electron microscopic image of a skin biopsy from a GOM-positive patient (#12).
Two GOM deposits located outside the smooth muscle cell membrane (arrowheads). Due to the plane of section and to the irregular indentations, the cytoplasm of a VSMC contains two GOM pseudoinclusions (arrows). Scale bar = 0.5 µm.
Figure 3.
Transmission electron microscopic image of a skin biopsy from a GOM-positive case (#2).
This dermal capillary shows a thickened basal membrane (bm) and is surrounded by pericytes (P). Numerous GOM deposits can be seen in the basal membrane and very often in close vicinity to pericytes. C, collagen; EC, endothelial cell; L, capillary lumen. Scale bar = 0.6 µm.
Figure 4.
Transmission electron microscopic image of a skin biopsy from a GOM-positive case (#5).
GOM located in an infolding of a VSMC. The cell membrane shows numerous pinocytotic vesicles close to the GOM deposit (arrowheads). C, collagen; bm, basal membrane. Scale bar = 0.2 µm.