Table 1.
Socio-demographic and clinical characteristics of HC and PD subjects.
Figure 1.
Representative immunophenotype plots of the whole blood sample from one HC subject are reported to show the gating strategy. Total cells were identified in a forward scatter (FSC)/side scatter (SSC) plot and gated (R1, left panel A). Then DC were identified by gating lineage negative (Lin−) cells (R2, middle panel B). Finally, myeloid DC (R3) were identified by CD11c and HLA-DR expression, while plasmacytoid DC (R4) were identified by CD123 and HLA-DR expression (right panel C).
Figure 2.
The distribution of percentage values (upper panels) and total counts (lower panels) of pDC (left panels) and mDC (right panels) present in blood of HC (n = 80) and PD (n = 80) subjects is reported in the respective box-and-whisker plot, as indicated.
Figure 3.
Blood DC decline in PD subgroups.
The distribution of percentage values (upper panels) and total counts (lower panels) of pDC (left panels) and mDC (right panels) present in blood of HC (n = 80), dopaminergic drug-treated PD (T-PD, n = 73) and drug naïve PD (U-PD, n = 7) subjects is reported in the respective box-and-whisker plot, as indicated.
Figure 4.
Lack of association between blood DC levels and LED in PD.
The correlation of L-dopa equivalent dose with percentage values (upper panels) and total counts (lower panels) of pDC (left panels) and mDC (right panels) present in blood of PD (n = 80) subjects is reported in the respective scatter plot, as indicated. Lines represent linear regression.
Figure 5.
Blood DC association with somatic depression severity in PD.
The correlation of BDI SOM scores with percentage values (upper panel) and total counts (lower panel) of mDC present in blood of PD (n = 80) subjects is reported in the respective scatter plot, as indicated. Lines represent linear regression.
Figure 6.
Blood DC association with motor symptom severity in PD.
The correlation of UPDRS III score with percentage values (upper panels) and total counts (lower panels) of pDC (left panels) and mDC (right panels) present in blood of PD patients (n = 80) is reported in the respective scatter plot, as indicated. Lines represent linear regression.