Figure 1.
(A) Chest radiography showing diffuse, ill-defined ground-glass opacities and several ill-defined small nodular opacities in both lungs (in the 4 weeks after respiratory symptoms started). (B) Chest computed tomography showing diffuse centrilobular nodules in both lungs, with ground-glass opacities suggestive of peribronchiolar fibrosis (in the 4 weeks after respiratory symptoms started). (C) The most striking histological feature, interstitial thickening and fibrosis with a centrilobular distribution and relative sparing of the subpleural parenchyma (upper one-third). Original magnification ×40. (D) Interstitial fibroblasts proliferating in a pale myxoid stroma (arrows) and collapsed alveolar spaces lined by activated pneumocytes (arrowhead). Original magnification ×200.
Table 1.
Socio-demographic and clinical characteristics of the 16 children with children’s interstitial lung diseases and their 47 matched controls.
Table 2.
Comparison of indoor environmental factors between the16 children with children’s interstitial lung diseases and their 47 matched control.
Table 3.
Comparison of outdoor environmental factors between the16 children with children’s interstitial lung diseases and their 47 matched controls.
Table 4.
Univariate analysis of the association between the use of a humidifier disinfectant and the risk of children’s interstitial lung diseases in 1∶3 matched case and control.