Table 1.
Baseline Characteristics of the Participants, According to Study Group.*
Figure 1.
Estimated global cognitive performance (z-score units) as a function of time in study.
Figure 1A shows results from a mixed-effects model without a change point added for initiation of a medication with anticholinergic activity and Figure 1B shows results from a model with a change point. The blue line shows average global cognitive performance over time for a typical person (75-year-old female with 18 years of education) who never used an anticholinergic medication. The green line shows average cognitive function over time for a typical person who was taking a medication with anticholinergic activity at baseline. The black line shows average global cognitive function over time for a typical person who first started anticholinergic medication after 4.5 years.
Table 2.
Annual rate of change in global cognitive functions by user group.
Table 3.
Annual rate of change in episodic memory by user group.