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Figure 1.

Analytic Decision Tree and Markov model of patients according to screening and treatment status.

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Table 1.

Key Model Assumptions.

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Table 2.

Cost-effectiveness ratio.

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Figure 2.

Costs of different strategies according to their effectiveness and the CP intervention cost.

The strategies included in quadrant I were more effective and more costly than “Screening strategy without CP”. The strategies included in quadrant II were less effective and more costly (dominated); the strategies included in quadrant III were less effective and less costly; and the strategies included in quadrant IV were more effective and less costly (dominant). The slope of the line between any two points represents the incremental cost-effectiveness ratio for two pathways.

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Table 3.

The results of the one-way sensitivity analysis.

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Table 3 Expand

Figure 3.

Incremental cost-effectiveness for the 10 000 Monte Carlo simulations on the cost-effective plane.

The scatterplots show the distribution of the incremental cost-effectiveness ratio for the different strategies. The ellipses show the central 95th percentile of each distribution. The overlaid lines have slopes that are equal to the willingness-to-pay threshold (€40000).

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