Figure 1.
Illustration of the virtual reality fear conditioning paradigm used here.
(A) Design of the experimental task. (B) Overview of the movie composition from a single acquisition block of the virtual reality fear conditioning task. Adapted from [38].
Table 1.
Frequencies and statistics (Hardy-Weinberg equilibrium, linkage equilibrium and gender distribution) of the genetic polymorphisms under study are shown.
Table 2.
Frequencies, N per cell, age, STAI-T, NEO-N, shock intensity, baseline startle amplitude and percentage of null-responses per experimental phase are displayed for all possible genotype combinations, and for the whole sample.
Figure 2.
Acquisition of conditioned fear responses depends on an interaction between 5HTTLPR and CRHR1 (rs878886).
Potentiated conditioned fear responses to the threat cue (A) and the threat context (B) during the acquisition phase and the expression phase are plotted as a function of both genotypes. Significant effects denoted are in (A) the main effect of CRHR1 on cued fear during acquisition, defined as the contrast between light on/CXT+ vs. light off/CXT+, and in (B) the interaction between 5HTTLPR and CRHR1 (rs878886) on contextual anxiety during acquisition, quantified as the contrast light off/CXT+ vs. light off/CXT–. Error bars display ±1 standard error of the mean *P<0.05; #P<0.10.