Table 1.
Demographic, clinical and MRI characteristics for controls (n = 25) and patients (n = 36).
Table 2.
Correlations between MRI measures of global GM and WM damage and clinical scores (EDSS and MSFC subscales).
Figure 1.
Differences in GM volume between patients and controls.
GM volume is decreased in patients group in comparison to controls. Differences are evident in the cerebellum, thalamus, subgenual gyrus, middle cingulate cortex, superior frontal gyrus, occipital and temporal cortices, bilaterally. Clusters of significant differences are superimposed on sagittal, coronal and axial slices of the single-subject T1 template provided with SPM8. (VBM analysis, SPM 8, two-sample, p<0.05, FWE corrected; t value are shown).
Figure 2.
Correlation between GM volume in patients and MSFC subscales.
On the top of the figure, GM volume negatively correlates with 9HPTD score at cerebellum level. On the bottom of the figure, GM volume positively correlates with PASAT 2 s at level of orbitofrontal cortex. Clusters of significant correlations are superimposed on sagittal, coronal and axial slices of the single-subject T1 template provided with SPM8. (VBM analysis, SPM 8, one-sample, p<0.05, FWE corrected; t values are shown).
Figure 3.
Differences in DTI measures between patients and controls.
Statistical maps showing voxels which exhibit differences in DTI parameters in patients versus controls (red and yellow colours, according to the lower and higher significance, respectively ). FA is significantly decreased and MD, AD, RD are increased in patients group in comparison to controls. Differences are widespread and evident in the corona radiata, corpus callosum, internal and external capsule, superior cerebellar peduncles, superior and inferior longitudinal fasciculum, posterior thalamic radiations and cerebral peduncle bilaterally. All WM tracts are overlaid on MNI152 1 mm standard image.(TBSS analysis, two-sample, p<0.05, tfce corrected).
Figure 4.
Correlation between FA in patients and MSFC subscales.
Statistical map showing voxels which correlate with clinical scores. a) FA negatively correlates with 9HPT score obtained with dominant and non-dominant hand in corpus callosum, internal and external capsule, posterior thalamic radiations, cerebral peduncles. FA is positively correlated with the PASAT score at 2 seconds in the internal and external capsule, corpus callosum, posterior thalamic radiations, cerebral peduncles (red and yellow colours according to the lower and higher significance, respectively). b) WM tracts with reduced FA that are common to the WM skeletons resulted by the correlation between FA values and 9HPTD, 9HPTND and PASAT 2 s. All WM tracts are overlaid on MNI152 1 mm standard image. (TBSS analysis, one-sample, p<0.05, tfce corrected).