Figure 1.
Region-level imaging comparison of lvPPA and DAT.
Age-adjusted odds ratios and 95% CIs on the logarithm scale for a 1-SD change in the imaging variable. The vertical dashed line represents an odds ratio of 1.0. Estimates to the left of the vertical line indicate pathology tended to be greater in lvPPA. Estimates to the right of the vertical line indicate pathology tended to be less in lvPPA. 95% CIs that do not cross the dashed line represent significant differences between groups.
Table 1.
Subject demographics.
Figure 2.
Voxel-level imaging findings in lvPPA and DAT when compared to controls.
Three dimensional renderings show regions of reduced FDG metabolism and gray matter (GM) volume in lvPPA compared to controls and in DAT compared to controls. All images were generated using an FDR corrected statistical threshold of p<0.0005 and an extent threshold of 100 voxels. A decrease in brightness of the render reflects increased distance from the surface of the tissue.
Figure 3.
Voxel-level imaging comparison of lvPPA and DAT.
Three dimensional renderings show regions of reduced FDG metabolism and gray matter (GM) volume in lvPPA compared to DAT, and in DAT compared to lvPPA. All images were generated using an uncorrected statistical threshold of p<0.001 and an extent threshold of 100 voxels. A decrease in brightness of the render reflects increased distance from the surface of the tissue.
Figure 4.
Estimated coefficients from multivariable penalized logistic regression analyses.
Estimated AUROC and a 95% bootstrap confidence interval are shown in the top left of each panel.