Table 1.
Demographic and clinical data.
Figure 1.
Functional working-memory related correlates in PD and controls during the encoding phase.
Regions showing significantly lower activity (yellow) in PD relative to healthy controls during the encoding phase of the motor WM task. All significant effects are displayed on the MNI single subject template and the color bar represents T-values.
Figure 2.
Functional working-memory related correlates in PD and controls during direct and delayed recall.
A–C) Regions showing significantly lower activity (yellow) in PD relative to healthy controls during A) direct recall and B) delayed recall. C) Regions showing significantly higher activity (blue) in PD relative to healthy controls during delayed recall. All significant effects are displayed on the MNI single subject template and the color bar represents T-values.
Figure 3.
Functional working-memory related correlates in PD and controls during load-related modulation.
A–B) Regions showing significantly lower load-related modulation in PD during the encoding phase A) and delayed recall B). C) Regions showing significantly higher load-related modulation in PD relative to healthy controls during delayed recall. All significant effects are displayed on the MNI single subject template and the color bar represents T-values.
Figure 4.
Schematic overview of working-memory related activation patterns in PD and controls.
Schematic summary of brain regions showing task- or load-related differences during the delayed recall condition representing memory - motor transformation.
Table 2.
Reduced working memory related functional MRI results in PD compared to controls.
Table 3.
Increased working memory related activation in PD.
Table 4.
Condition by group interaction.